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. 2021 Jan 4;11:9. doi: 10.1038/s41398-020-01132-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A The volcano plot for the differential metabolites in CUMS and CON groups; red nodes = P < 0.05. B The heat plot for the differential metabolites in CUMS and CON groups. C The pathway analysis of differential metabolites of CUMS and CON groups in MetaboAnalyst; red nodes = P < 0.05. D A simplified interaction diagram of the altered pathways in CUMS and CON groups. Metabolites in green decreased. E A simplified interaction diagram of altered pathways between adolescent depression monkeys and patients. Metabolites in green decreased.