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. 2021 Jan 5;12(1):40. doi: 10.1038/s41419-020-03323-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A, B Luciferase assay data showed that HOXA5 activated the expression of p53 promoter reporter gene in KFb and HSFb. C, D ChIP data showed a direct interaction between HOXA5 and p53. 6 kb:the 6 kb upstream of the transcription start site, was used as a negative control for the transcription start site. E, F qPCR and western blot data showed that the overexpression of HOXA5 enhanced the expression of p21 and Mdm2, which are downstream targets of p53. *p < 0.05, **p < 0.01.