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. 2021 Jan 7;11:7. doi: 10.1038/s41398-020-01156-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Timeline of experiment. b Kaplan–Meier survival curve (left) and scatterplot (right) of NSF data showing individual latency to eat values across all four groups. c–e Left panels represent Two-way ANOVA of all treatment groups and right panels represent One-Way ANOVA of CORT+VEH, CORT+FLX responders, and CORT+FLX non-responders for: EPM open arm entries and open arm duration (c), FST immobility (d), and Negative Affect Index (e). f Regression analyses correlating NSF latency to eat with EPM open arm duration (left) and FST immobility (right). g In a separate cohort of CORT+FLX mice, persistence of response was determined by assessing NSF behavior after 3 weeks of FLX (time point 0), and then again 1, 4, and 6 months later. For the NSF survival curve, line shading shows SEM of each group (n = 15–23 per group). Scatterplots, horizontal lines, and bars show group means with error bars indicating SEM (n = 7–16 per group after CORT+FLX mice are divided into responders and non-responders).