Table 3. Associations between pre-diabetes and mortality by hypertension status.
| Groups | Case/total | Model 1 (N=34,047) | Model 2 (N=34,047) | Model 3 (N=29,413) |
|---|---|---|---|---|
| HR for all-cause mortality (95% CI) | ||||
| PreDM(−) & HTN(−) | 747/18,451 | Ref. | Ref. | Ref. |
| PreDM(+) & HTN(−) | 405/5,714 | 2.33 (2.07, 2.63)** | 0.94 (0.83, 1.06) | 1.05 (0.92, 1.20) |
| PreDM(−) & HTN(+) | 1083/4,871 | 6.09 (5.55, 6.68)** | 1.24 (1.12, 1.37)** | 1.30 (1.16, 1.45)** |
| PreDM(+) & HTN(+) | 1115/5,011 | 7.61 (6.94, 8.36)** | 1.24 (1.12, 1.38)** | 1.37 (1.22, 1.54)** |
| P for trend | <0.001 | <0.001 | <0.001 | |
| HR for cardiovascular mortality (95% CI) | ||||
| PreDM(−) & HTN(−) | 66/18,451 | Ref. | Ref. | Ref. |
| PreDM(+) & HTN(−) | 47/5,714 | 2.95 (2.03, 4.30)** | 1.01 (0.69, 1.48) | 1.24 (0.83, 1.84) |
| PreDM(−) & HTN(+) | 190/4,871 | 11.92 (9.01, 15.77)** | 1.87 (1.39, 2.51)** | 1.89 (1.36, 2.61)** |
| PreDM(+) & HTN(+) | 227/5,011 | 16.84 (12.79, 22.17)** | 2.08 (1.55, 2.78)** | 2.11 (1.52, 2.92)** |
| P for trend | <0.001 | <0.001 | <0.001 | |
**, P<0.01. Model 1: unadjusted; Model 2: adjusted for age and gender; Model 3: adjusted for age, gender, smoking, education, race, body mass index, cardiovascular disease at baseline, cancer at baseline, total cholesterol, high-density-lipoprotein cholesterol, dietary energy intake, estimated glomerular filtration rate, the use of statin or antiplatelet drugs. DM, diabetes mellitus; HTN, hypertension; HR, hazard ratio; CI, confidence interval.