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. 2020 Dec;8(23):1587. doi: 10.21037/atm-20-2108

Table 2. Description of population-based cohort of patients with urothelial bladder cancer.

Variables Total 1993–2002 2003–2012 P value1
N 220,405 69,314 151,091
Age, year, mean ± SD 70.84±12.08 70.16±12.16 71.15±12.03 <0.001
   <35 1,204 (0.55) 483 (0.70) 721 (0.48) <0.001
   35–44 4,099 (1.86) 1,653 (2.38) 2,446 (1.62)
   45–54 16,526 (7.50) 5,649 (8.15) 10,877 (7.20)
   55–64 40,606 (18.42) 12,214 (17.62) 28,392 (18.79)
   65–74 64,413 (29.22) 21,490 (31.00) 42,923 (28.41)
   ≥75 93,557 (42.45) 27,825 (40.14) 65,732 (43.50)
Race, n (%) <0.001
   White 198,035 (89.85) 62,334 (89.93) 135,701 (89.81)
   Black 11,875 (5.39) 3,780 (5.45) 8,095 (5.36)
   Other 9,056 (4.11) 2,965 (4.28) 6,091 (4.03)
   Unknown 1,439 (0.65) 235 (0.34) 1,204 (0.80)
Sex, n (%) <0.001
   Male 167,036 (75.79) 51,868 (74.83) 115,168 (76.22)
   Female 53,369 (24.21) 17,446 (25.17) 35,923 (23.78)
Grade, n (%) <0.001
   Grade I 31,428 (14.26) 11,867 (17.12) 19,561 (12.95)
   Grade II 64,916 (29.45) 25,870 (37.32) 39,046 (25.84)
   Grade III 49,409 (22.42) 19,576 (28.24) 29,833 (19.75)
   Grade IV 46,654 (21.17) 7,560 (10.91) 39,094 (25.87)
   Unknown 27,998 (12.70) 4,441 (6.41) 23,557 (15.59)
Histology, n (%) <0.001
   Localized 171,208 (77.68) 53,523 (77.22) 117,685 (77.89)
   Regional 39,607 (17.97) 12,491 (18.02) 27,116 (17.95)
   Distant 6,663 (3.02) 1,915 (2.76) 4,748 (3.14)
   Unstaged 2,927 (1.33) 1,385 (2.00) 1,542 (1.02)
T stage, n (%) <0.001
   <T2 172,161 (78.11) 53,611 (77.35) 118,550 (78.46)
   ≥T2 44,841 (20.34) 14,295 (20.62) 30,546 (20.22)
   Tx 3,403 (1.54) 1,408 (2.03) 1,995 (1.32)
Median household income2, n (%) <0.001
   Low 122,036 (55.37) 36,389 (52.50) 85,647 (56.69)
   High 98,341 (44.62) 32,915 (47.49) 65,426 (43.30)
   Unknown 28 (0.01) 10 (0.01) 18 (0.01)
Marital status, n (%) <0.001
   Married 134,142 (60.86) 43,745 (63.11) 90,397 (59.83)
   Previous married 51,436 (23.34) 16,411 (23.68) 35,025 (23.18)
   Never married 20,786 (9.43) 6,150 (8.87) 14,636 (9.69)
   Unknown 14,041 (6.37) 3,008 (4.34) 11,033 (7.30)
With previous primary, n (%) <0.001
   No 166,112 (75.37) 54,558 (78.71) 111,554 (73.83)
   Yes 54,293 (24.63) 14,756 (21.29) 39,537 (26.17)
Cancer-directed surgery, n (%) <0.001
   No3 12,067 (5.47) 3,502 (5.05) 8,565 (5.67)
   Yes 207,845 (94.30) 65,711 (94.80) 142,134 (94.07)
   Unknown 493 (0.22) 101 (0.15) 392 (0.26)

1, comparison between 1993–2002 and 2003–2012; 2, median household income: defined by earnings above the median of the median household income in this sample; 3, including “no surgical procedure”, “needle, or aspiration biopsy” or “Non-cancer directed surgery”. Grade I = well differentiated; Grade II = moderately differentiated; Grade III = poorly differentiated; Grade IV = undifferentiated; anaplastic. UBC, urothelial bladder cancer; SD, standard deviation.