Table 1.
Characteristics and survival in patients with osteoclast-like giant cell-containing pancreatic undifferentiated carcinoma
| Reference | Gender/Age, years | Location | Maximal tumor dimension, cm | Associated with AC | IHC | Therapy | Survival, months | Invasion of other organ | lymph node | LVI | Resection margin |
|---|---|---|---|---|---|---|---|---|---|---|---|
| F/82 | tail | 13 | No | NA | NA | >4 | NA | Neg | NA | NA | |
| 1 | F/74 | head | 10 | No | NA | NA | >10 | NA | Neg | Yes | NA |
| 2 | M/60 | body, tail | 14 | No | GC: vimentin(+), syn(+), CK(-), EMA(-) | NA | 4 | NA | Neg | NA | NA |
| 6 | F/37 | head | 4 | Yes | GC: vimentin(+), p53(-), AC: p53(+) | Gemcitabine | >66 | NA | Neg | NA | No |
| 7 | F/61 | tail | 10.4 | NA | NA | Gemcitabine | >72 | Left diaphragm | Neg | Yes | No |
| 9 | F/55 | body | 2.5 | Yes | PC&MC: CK(+), viminetin(+), OGC: vimentin(-), AC: CA199(+), CK(+) | NA | 3 | Liver | Neg | NA | NA |
| 9 | F/71 | head | 4.5 | NA | OGC&PGC: EMA(-), vimentin(-), CK(-)desmin(-), SMA(-) | NA | 2 | No | Neg | Yes | NA |
| 9 | M/50 | body | 7 | NA | OGC: CK(-), CD68(+), PGC: CK(+), CD68(-) | NA | 7 | NA | NA | NA | NA |
| 10 | F/72 | head | 6.5 | No | NA | NA | Dead 10 days after admission | Liver, adrenal gland | NA | NA | NA |
| 11 | F/56 | tail | 24 | Yes (focal) | vimentin(+), EMA(-) | Radiation | >6 | NA | NA | Yes | NA |
| 12 | F/68 | neck, body | 6 | No | PC&MC: CK8/18(+), CK19(+), vimentin(+), ki-67(+, 30%); OGC: CD68(+), vimentin(+), CK8/18(-), CK19(-), ki-67(-) | Gemcitabine | 10 | No | Neg | No | No |
| 13 | M/49 | head | 2 | Yes | OGC, MC: CD68(+), AE1/AE3(-) | NA | NA | No | NA | NA | NA |
| 13 | F/68 | body, tail | 14 | No | OGC, MC: CD68(+), AE1/AE3(-) | NA | NA | Liver | NA | NA | NA |
| 13 | M/51 | head | 3.8 | Yes | PC: CD68(-), AE1/AE3(-) | NA | NA | NA | Pos | NA | NA |
| Present case | M/54 | tail | 20.4 | No | OGC: CD68(+), PC: focal weak CK(+), ki-67(+, <5%) | No | >84 | No | Neg | No | Neg |
Note: AC: adenocarcinoma; CK: cytokeratin; EMA: epithelial membrane antigen; F: female; GC: giant cell; IHC: immunohistochemistry; LVI: lymphovascular invasion; M: male; MC: mononuclear cell; NA: not available; Neg: negative; OGC: osteoclast-like giant cell; PC: pleomorphic cell; PGC: pleomorphic giant cell; Pos: positive; Ref: reference; SMA: smooth muscle actin; Syn: synaptophysin.