Table 3.
Univariate and multivariate analyses of overall survival in breast cancer patients
| Variables | Category | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|---|
|
|
|
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| HR | 95% CI | P-value | HR | 95% CI | P-value | ||
| Age (Years) | > 35 vs. ≤ 35 | 1.225 | 0.543-2.612 | 0.628 | |||
| Tumor size | T2, T3 vs. T1 | 1.440 | 0.678-3.095 | 0.341 | |||
| Histological grade | Grade 3 vs. grade 1, 2 | 1.617 | 0.694-4.382 | 0.285 | |||
| ER | Negative vs. positive | 3.018 | 1.408-6.836 | 0.005 | 2.742 | 1.276-6.230 | 0.012 |
| PR | Negative vs. positive | 2.020 | 0.949-4.364 | 0.076 | |||
| HER2 | Positive vs. negative | 3.890 | 1.625-9.919 | 0.003 | 4.626 | 1.873-12.032 | 0.001 |
| Lymph node metastasis | Positive vs. negative | 1.775 | 0.656-6.190 | 0.284 | |||
| TNM stage | III vs. I + II | 2.936 | 1.211-7.485 | 0.017 | 1.703 | 0.579-5.548 | 0.349 |
| Ki-67 status | ≥ 20% vs. < 20% | 1.071 | 0.404-2.628 | 0.884 | |||
| P53 status | Negative vs. positive | 1.595 | 0.647-3.821 | 0.302 | |||
| SOX12 | Positive vs. negative | 3.129 | 1.386-7.024 | 0.006 | 2.532 | 1.154-5.586 | 0.023 |
HR, hazard ratio; CI, confidence interval; ER, estrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor receptor 2; TNM, tumor-node-metastasis; SOX12, sex-determining region Y-box 12; P-values that reach significance are in bold.