Table 4.
Univariate and multivariate analyses of distant metastasis-free survival in breast cancer patients
| Variables | Category | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|---|
|
|
|
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| HR | 95% CI | P-value | HR | 95% CI | P-value | ||
| Age (Years) | > 35 vs. ≤ 35 | 1.194 | 0.827-1.721 | 0.343 | |||
| Tumor size | T2, T3 vs. T1 | 1.208 | 0.793-1.841 | 0.379 | |||
| Histological grade | Grade 3 vs. grade 1, 2 | 1.094 | 0.720-1.665 | 0.676 | |||
| ER | Negative vs. positive | 1.705 | 1.117-2.605 | 0.014 | 1.248 | 1.054-1.915 | 0.031 |
| PR | Negative vs. positive | 1.184 | 0.985-1.424 | 0.073 | |||
| HER2 | Positive vs. negative | 1.048 | 0.683-1.604 | 0.830 | |||
| Lymph node metastasis | Positive vs. negative | 2.473 | 1.584-3.879 | < 0.001 | 1.837 | 1.129-2.994 | 0.019 |
| TNM stage | III vs. I + II | 1.360 | 0.654-2.857 | 0.429 | |||
| Ki-67 status | ≥ 20% vs. < 20% | 1.585 | 0.552-4.544 | 0.405 | |||
| P53 status | Negative vs. positive | 1.061 | 0.370-3.042 | 0.926 | |||
| SOX12 | Positive vs. negative | 1.907 | 1.238-2.943 | 0.003 | 1.724 | 1.028-2.636 | 0.012 |
HR, hazard ratio; CI, confidence interval; ER, estrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor receptor 2; TNM, tumor-node-metastasis; SOX12, sex-determining region Y-box 12; P-values that reach significance are in bold.