Figure 3.

Upregulation of SIRT1 improved surgery-induced cognitive dysfunction in aged mice. (A) The crossing frequency and (B) total distance between the two groups during the open field test. (C) The latency to platform (time to find the hidden platform) in the MWM training trials. (D) The percentage of time spent in the target quadrant. (E) The swimming trajectory of mice. (F) The platform crossing times. (G) Latency for the first time to platform and (H) the swimming speed in each group during the MWM probe trials. (I) Image of western blot protein bands. (J) Quantification for SIRT1. (K) Relative expression of SIRT1 mRNA in the hippocampus. Data were presented as mean ± SEM. *P < 0.05, **P < 0.01.