Table 3.
Distribution of the alleles and genotypes of the polymorphisms investigated in the B-cell ALL patients, in comparison with control individuals
| Genotype ID | Case (%) | Control (%) | p | Model | OR (95% CI) |
|---|---|---|---|---|---|
| AGO1_rs636832 | 75 | 150 | |||
| AA | 8 (10.7) | 14 (9.3) | |||
| AG | 34 (45.3) | 67 (44.7) | AA + AG vs. GG | ||
| GG | 33 (44) | 69 (46) | 0.163 | Recessive | 1.687 (0.809-3.520) |
| Allele A | 0.333 | 0.316 | |||
| Allele G | 0.666 | 0.683 | |||
| DROSHA_rs10035440 | 80 | 148 | |||
| TT | 60 (75) | 98 (66.2) | |||
| TC | 17 (21.3) | 44 (29.7) | TT + TC vs. CC | ||
| CC | 3 (3.8) | 6 (4.1) | 0.434 | Recessive | 2.082 (0.331-13.085) |
| Allele T | 0.856 | 0.810 | |||
| Allele C | 0.143 | 0.189 | |||
| DROSHA_rs3805500 | 74 | 159 | |||
| GG | 11 (14.9) | 50 (31.4) | |||
| GA | 26 (35.1) | 51 (32.1) | GG + GA vs. AA | ||
| AA | 37 (50) | 58 (36.5) | 0.004 | Recessive | 2.913 (1.415-5.998) |
| Allele G | 0.324 | 0.474 | |||
| Allele A | 0.675 | 0.525 | |||
| MIR219-1_rs213210 | 82 | 166 | AA vs. AG + GG | ||
| AA | 64 (78) | 134 (80.7) | 0.813 | Dominant | 0.908 (0.409-2.015) |
| AG | 16 (19.5) | 19 (11.4) | |||
| GG | 2 (2.4) | 13 (7.8) | |||
| Allele A | 0.878 | 0.864 | |||
| Allele G | 0.121 | 0.135 | |||
| MIR219-1_rs107822 | 73 | 152 | CC vs. CT + TT | ||
| CC | 36 (49.3) | 85 (55.9) | 0.831 | Dominant | 0.929 (0.471-1.832) |
| CT | 30 (41.1) | 53 (34.9) | |||
| TT | 7 (9.6) | 14 (9.2) | |||
| Allele C | 0.698 | 0.733 | |||
| Allele T | 0.301 | 0.266 | |||
| MIR146A_rs2910164 | 81 | 160 | GG vs. GC + CC | ||
| GG | 47 (58) | 68 (42.5) | 0.091 | Dominant | 1.777 (0.912-3.462) |
| GC | 24 (29.6) | 74 (46.3) | |||
| CC | 10 (12.3) | 18 (11.3) | |||
| Allele G | 0.728 | 0.656 | |||
| Allele C | 0.271 | 0.343 | |||
| MIR300_rs12894467 | 76 | 175 | TT vs. TC + CC | ||
| TT | 22 (28.9) | 75 (42.9) | 0.062 | Dominant | 0.513 (0.254-1.035) |
| TC | 42 (55.3) | 80 (45.7) | |||
| CC | 12 (15.8) | 20 (11.4) | |||
| Allele T | 0.565 | 0.657 | |||
| Allele C | 0.474 | 0.342 | |||
| MIR499_rs3746444 | 75 | 167 | |||
| AA | 5 (6.7) | 126 (75.4) | |||
| AG | 43 (57.3) | 36 (21.6) | AA + AG vs. GG | ||
| GG | 27 (36) | 5 (3.0) | <0.001 | Recessive | 17.797 (5.55-57.016) |
| Allele A | 0.353 | 0.862 | |||
| Allele G | 0.646 | 0.137 | |||
| MIR608_rs4919510 | 81 | 161 | GG vs. GC + CC | ||
| GG | 5 (6.2) | 18 (11.2) | 0.325 | Dominant | 0.566 (0.182-1.760) |
| GC | 29 (35.8) | 58 (36) | |||
| CC | 47 (58) | 85 (52.8) | |||
| Allele G | 0.240 | 0.291 | |||
| Allele C | 0.759 | 0.708 | |||
| MIR938_rs2505901 | 76 | 150 | CC vs. CT + TT | ||
| CC | 15 (19.7) | 53 (35.3) | 0.013 | Dominant | 0.359 (0.160-0.805) |
| CT | 38 (50) | 46 (37.7) | |||
| TT | 23 (30.3) | 51 (34) | |||
| Allele C | 0.447 | 0.506 | |||
| Allele T | 0.552 | 0.493 |
OR: Odds Ratio; CI: Confidence interval. The p values refer to the logistic regression adjusted for sex and Amerindian ancestry.