Table. Genetic changes that characterise 501Y Variant 1 and Variant 2a and occurred in the genetic branches preceding their lineages.
| Gene | 501Y Variant 1 | 501Y Variant 2a |
|---|---|---|
| Spike | N501Y | H69, V70 deletion |
| Y144 deletion | ||
| N501Y | ||
| A570D | ||
| P681H | ||
| T716I | ||
| S982A | ||
| D1118H | ||
| ORF1ab | S944L | T1001I |
| H2357Y | A1708D | |
| P3395L | I2230T | |
| M6723I | S3675, G3676, F3677 deletion | |
| ORF7a | T14I | – |
| ORF8 | – | Q27 stop |
| R52I | ||
| Y73C | ||
| Nucleocapsid | – | D3L |
| S235F |
Only amino acid changes are shown.
a 501Y Variant 2 was also named B.1.1.7 by COVID-19 Genomics Consortium UK (CoG-UK) [3], 20B/501Y.V1 by Nextstrain (https://nextstrain.org/) and VOC-202012/01 by Public Health England [4].
The most concerning mutation is indicated in bold.