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. 2020 Nov 16;5(1):pkaa109. doi: 10.1093/jncics/pkaa109

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© The Author(s) 2020. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Assessment of linearity. Relative cancer rates for age-adjusted PhenoAge, GrimAge, and predicted telomere length for 7 cancer types and overall in the Melbourne Collaborative Cohort Study. Model 1 was used (no other adjustment than that provided by the matching variables). x-axis: methylation-based measures of aging. All measures were expressed as Z scores (mean = 0, SD = 1), so that approximately 95% of the values are between –2 and 2. y-axis: Relative cancer rate, using as a reference (y = 1) the median value of the methylation-based measure distribution. P values (P-lin) are from a likelihood ratio test comparing P-spline and linear models.