Table 1.

Digitally quantified CD3, CD4, CD8, CD20 and CD45RO density (cells/mm²) and their distribution and correlation with clinicopathological variables (chi-square and Fisher’s exact tests)

	CD3			CD4			CD8			CD20			CD45RO
	≤1000	>1000	P	≤550	>550	P	≤500	>500	P	≤400	>400	P	≤250	>250	P
Age			0.624			0.029			0.856			0.573			0.263
≤65	159	62		146	74		101	121		178	45		149	72
>65	225	78		173	133		141	161		253	55		190	115
Gender			0.004			0.788			0.783			0.122			0.946
Female	112	60		103	70		77	94		135	40		110	62
Male	272	80		216	137		165	188		296	60		229	125
Weight loss			0.791			0.328			0.082			0.936			0.699
<10%	346	127		283	189		211	259		388	90		303	169
>10%	38	12		36	17		31	22		43	9		36	17
Smoking			0.589			0.635			0.096			0.002			0.882
Never	11	6		9	9		10	8		15	3		12	6
Present	242	91		204	129		142	191		260	78		212	121
Previous	131	43		106	69		90	83		156	19		115	60
ECOG			0.029			0.259			0.166			0.106			0.012
0	215	96		181	131		133	178		244	68		186	125
1	139	38		116	61		91	87		154	28		124	55
2	30	6		22	15		18	17		33	4		29	7
Histology			0.040			0.118			0.574			0.573			0.109
LUSC	221	72		191	104		136	155		245	52		188	106
LUAD	160	64		124	101		105	121		180	47		147	78
LULCC	0	3		1	1		0	3		2	1		0	3
LUADSC	2	1		2	1		1	2		3	0		3	0
NOS	1	0		1	0		0	1		1	0		1	0
tStage			0.653			0.031			0.270			0.270			0.342
T1a	8	3		6	7		7	4		9	4		9	3
T1b	44	23		39	29		30	38		53	16		46	22
T1c	67	25		49	43		41	50		69	23		58	34
T2a	89	34		74	48		53	71		103	22		73	48
T2b	53	19		39	33		28	43		59	13		40	32
T3	75	25		67	35		48	52		86	15		73	29
T4	48	11		45	12		35	24		52	7		40	19
nStage			0.397			0.354			0.270			0.115			0.115
N0	258	102		216	146		163	197		288	77		229	133
N1	86	24		66	45		49	62		98	14		69	42
N2	40	14		37	16		30	23		45	9		41	12
pStage			0.118			0.001			0.015			0.067			0.029
I	150	66		124	94		95	121		168	51		138	78
II	129	47		99	80		73	105		150	31		105	74
III	105	27		96	33		74	56		113	18		96	35
Differentation			0.071			0.907			0.715			0.676			0.235
Well	149	70		128	87		97	122		182	39		132	87
Intermediate	179	53		144	91		108	122		186	48		155	76
Poor	56	17		47	29		37	38		63	13		52	24
Vasc+			1.000			0.464			0.238			0.249			1.000
No	315	113		257	173		192	237		349	86		278	153
Yes	68	25		60	33		48	44		80	13		59	33

P-values below 0.05 are highlighted in bold. CD, cluster of differentiation; ECOG, eastern cooperative oncology group; NOS, no otherwise specified.