Table 2.
Adjusted odds of FISH + amp(1q) at diagnosis of multiple myeloma (n = 1768)a
| Variable name | OR (95% CI) |
|---|---|
| Age ≥70 yb | 1.25 (1.27 to 1.34) |
| Sex | |
| Female | 1.00 (Referent) |
| Male | 1.00 (0.94 to 1.08) |
| Race | |
| White | 1.00 (Referent) |
| African American | 1.12 (0.87 to 1.46) |
| Asianb | 1.59 (1.21 to 2.11) |
| Other | 1.14 (0.77 to 1.70) |
| Missingb | 0.67 (0.57 to 0.78) |
| R-ISS | |
| I | 1.00 (Referent) |
| IIb | 1.27 (1.01 to 1.60) |
| IIIb | 1.88 (1.24 to 2.85) |
| Missing | 0.75 (0.50 to 1.14) |
| Light chain type | |
| Non-lambda light chain | 1.00 (Referent) |
| Lambda light chainb | 1.31 (1.27 to 1.36) |
| Immunotype | |
| Non-IgA | 1.00 (Referent) |
| IgAb | 1.46 (1.38 to 1.55) |
| Cancer history | |
| No other cancer | 1.00 (Referent) |
| 1 other cancer | 1.10 (0.85 to 1.42) |
| ≥2 other cancersb | 2.77 (2.31 to 3.32) |
| No prostate cancer history | 1.00 (Referent) |
| Prostate cancer historyb | 2.06 (1.94 to 2.19) |
a
Multivariable logistic regression estimating associations between the presence of amp(1q) positivity (dependent variable) and independent variables of substantive interest. amp(1q) = amplification of the long arm of chromosome 1; CI = confidence interval; FISH = fluorescent in situ hybridization; R-ISS = revised international staging system.
b
Indicates associations with amp(1q) where 95% confidence interval does not include 1.00. The number of observations for the multivariable logistic regression is 1768 rather than 1769 because 1 member of the cohort (Table 1) had no value for the specific FISH test “amp(1q).”