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. 2021 Jan 7;12:45. doi: 10.1186/s13287-020-02112-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — micro-CT analysis of rat femur following intraperitoneal injection of Desferal®. a Schema of long-term Desferal administration of the in vivo study. b Representative three-dimensional micro-CT images of femurs in 2M, 12M-VEH, 12M-L-Desferal® (20 mg/kg), and 12M-H-Desferal® (60 mg/kg) groups. Bar = 1 mm. c Quantification of bone morphometric parameters of rat femur by micro-CT analysis. Significantly increased BV/TV, Tb.N and Coon.D and decreased Tb.Sp and SMI were observed in the 12M-H-Desferal® group when related to those of the 12M-VEH group. All of these parameters were statistically significant between the 2M and 12M-VEH groups. After Desferal® treatment, especially in the 12M-H-Desferal® group, bone mass increased significantly.BV/TV, bone volume/total volume; Tb.N, trabecular number; Tb.Th, trabecular thickness; Coon.D, trabecular connectivity density; Tb.Sp, trabecular separation; SMI, structural model index. *p < 0.05, **p < 0.01, ***p < 0.001