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. 2021 Jan 7;12:45. doi: 10.1186/s13287-020-02112-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Changes of cell senescence and ROS in BMSCs from rats with and without Desferal® treatment. a Representative images of SA-β-gal staining. Blue stained cells indicates positive for senescence. Bar = 200 μm. b Quantitative assessment the percent of SA-β-gal positive cells. The percentage of senescence cell was significantly reduced in BMSCs from the 12M-Desferal® group compared with that from the 12M-VEH group. **p < 0.01. c Reactive oxygen species (ROS)-induced fluorescence in BMSCs at cell slides was visualized by confocal microscopy. ROS could react with a fluorescence sensor to produce a fluorescent product named as 2′, 7′-dichlorodihydrofluorescein (DCF), which is proportional to the content of ROS. Bar = 200 μm. d ROS quantification of BMSC on a 96-well plate by microplate assays. Decreased intracellular ROS levels were observed in BMSCs from the 12M-H-Desferal® group compared with that from the 12M-VEH group. **p < 0.01