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. 2021 Jan 8;18:3. doi: 10.1186/s12979-021-00214-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Differential alterations in plasma cytokine content with age and sex. a Multiplex pro-inflammatory cytokine/chemokine analysis of plasma samples from young and aged male and female mice. b Plots show IFN-γ:IL-4 plasma concentration ratios of young and aged males and females. c Plots show TNF-α:IL-10 plasma concentration ratios of young and aged males and females. Young males (n = 8, 2–3 months); young females (n = 5, 2–3 months); aged males (n = 5, 18–19 months); aged females (n = 5, 18–19 months). Data were analyzed by 2-way ANOVA followed by Fisher’s LSD post hoc analysis. Data represent mean ± SEM. Comparisons within sex: *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Comparisons within age: #p < 0.05, ##p < 0.01, ###p < 0.001, ####p < 0.0001