Table 4.
HTLV-1/2 antibody assays used in the study
| Assay | Manufacturer | Assay type | Used antigens | Classification |
|---|---|---|---|---|
| Wantai HTLV-1/2 antibody ELISA kits | Wantai BioPharm, China | Double-antigen sandwich ELISA | Viral recombinant antigens gp21 | Screening assay in blood establishments |
| Foresight HTLV-1/2 antibody ELISA kits | Acon Biotech, China | Double-antigen sandwich ELISA | Viral recombinant antigens gp21 and gp46 | Screening assay in blood establishments |
| Murex HTLV I + II kits | Diasorin S.p.A., UK | Double-antigen sandwich ELISA | Synthetic env peptides of HTLV-1 and HTLV-2 and recombinant gag protein gp41 of HTLV-2 | Screening assay in blood establishments; supplemental testing assay in NCCL |
| Avioq HTLV-I/II Microelisa System | Avioq, North Carolina, United State | Double-antigen sandwich ELISA | Viral antigens (purified viral lysate) and recombinant HTLV-1 p21E antigen | Supplemental testing assay in NCCL |
| Elecsys HTLV-I/II | Roche Diagnostics, Germany | Electro-chemiluminescent (ECLIA) | Viral recombinant antigens gp21 and p24 | Supplemental testing assay in NCCL |
| Lumipulse G HTLV-I/II | Fujirebio, Japan | Chemiluminescent (CLIA) | Recombinant antigens p19 I/II, p24 I/II, and gp21 I | Supplemental testing assay in NCCL |
| MP HTLV Blot 2.4 | MP Biomedicals, Singapore | Western Blot (WB) | Recombinant HTLV-1/2 antigens and HTLV-1 viral lysate | Confirmatory testing assay in Fujian, Guangdong and Zhejiang |
| INNO-LIA HTLV I/II Score | Fujirebio, Japan | Line immunoassay | Recombinant antigens p19 I/II, p24 I/II, gp46 I/II, and gp21 I/II | Confirmatory testing assay in NCCL |