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. 2021 Jan 7;22:3. doi: 10.1186/s12860-020-00337-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Functional and structural characterization of recombinant APETx1 in patch-clamp recordings. a, b Current traces of hERG elicited by two different depolarization pulses, 0 mV (a) and 60 mV (b), before (black) and after (red) the administration of 10 μM APETx1. Voltage protocol is illustrated at the bottom of each current trace. c Normalized G-V curves (mean ± SEM) of hERG in the presence or absence of different APETx1 concentrations. d The ΔV_1/2 values of different concentrations of APETx1; these values indicate the toxin-induced shift of the half-maximal activation voltage of hERG