Table 5.
Unadjusted and adjusted odds ratios for the association between baseline pulmonary impairment and any pulmonary impairment at 12 months
| Unadjusted OR | 95% CI | Adjusted ORa | 95% CI | |
|---|---|---|---|---|
| Baseline normal lung function | Ref | Ref | ||
| Baseline obstruction | 1.67 | 0.36–7.76 | 1.95 | 0.28–13.78 |
| Baseline restriction | 3.24 | 1.06–9.87 | 5.44 | 1.16–25.45 |
| Baseline mixed | 5.83 | 0.84–40.32 | 9.00 | 1.05–76.87 |
| Age | 1.31 | 0.76–2.23 | ||
| Female Gender | 1.22 | 0.51–2.91 | ||
| CD4 baseline | 1.10 | 0.74–1.64 | ||
| CD4 change from baseline to week 4 | 0.81 | 0.53–1.23 | ||
| Log viral load baseline | 0.79 | 0.42–1.47 | ||
| Log viral load change from baseline to week 4 | 1.09 | 0.70–1.71 | ||
| Baseline HbA1c | 1.13 | 0.76–1.69 | ||
| Baseline CAT score | 1.24 | 0.82–1.87 | ||
| Final CAT score | 1.51 | 0.44–5.22 | ||
| Sputum TTP | 0.94 | 0.51–1.72 | ||
| Smoking (current) | 0.79 | 0.24–2.57 | ||
| Smoking (ever) | 0.95 | 0.31–2.91 | ||
| Time from TB treatment to ART | 1.02 | 1.00–1.04 |
Age: Categorized into < 30, 30–39, 40–49, > 50; Baseline CD4 categorized into < 50, 50–99, 100–199, > 200; CAT score < 5, 5–9, 10–15, > 15; HbA1c categorized into < 5.7, 5.7–5.9, 6.0–6.2, ≥ 6.3; CT involvement < 10, 10–15, > 15; TTP < 10, 10–15, 15–20, > 20
PFT pulmonary function test, OR odds ratio, 95% CI 95% confidence interval, HbA1c hemoglobin A1c, CAT COPD assessment test, TTP time to positivity, TB tx tuberculosis treatment, ART antiretroviral therapy, CT computed tomography
aAdjusted for age, gender, change in CD4 count from baseline to week 4, time from TB treatment to ART initiation. Statistically significant associations are indicated in bold