Table 2.
Global hemodynamic and transpulmonary thermodilution parameters. Comparison H0–H6
| H0 | H6 | ∆ H0–H6 (H6–H0) | p value** | |
|---|---|---|---|---|
| Heart rate (bpm) | 115 (110; 125) | 100 (92; 103) | − 18 (− 25; − 15) | 0.004 |
| SAP (mmHg) | 110 (102; 117) | 103 (99; 104) | − 9 (− 14; 1) | 0.16 |
| DAP(mmHg) | 54 (47; 55) | 55 (54; 59) | 4 (0; 8) | 0.12 |
| MAP (mmHg) | 72 (68; 72) | 72 (67; 75) | 0 (− 3; 4) | 0.52 |
| Double product (mm Hg.bpm) | 13,266 (12,138; 15,065) | 9682 (8736; 10,609) | − 2657 (− 3305; − 2628) | 0.008 |
| CI(L/min/m2) | 4.2 (3.1; 4.4) | 2.9 (2.5; 3.7) | − 0.6 (− 1.2; − 0.5) | 0.004 |
| SVi (mL/m2) | 29.8 (27.3; 37.8) | 28.2 (27.2; 36.5) | − 0.2 (− 5.2; − 0.0) | 0.25 |
| CPI (W/m2 | 0.61 (0.54; 0.70) | 0.48 (0.40; 0.58) | − 0.10 (− 0.17; − 0.06) | 0.008 |
| SVRi (dyn s m2 cm−5) | 1164 (1143; 1412) | 1379 (1333; 1876) | 190 (139; 427) | 0.004 |
| CFI (1/min) | 6.1 (4.8; 7.4) | 3.7 (3.5; 4.8) | − 1.9 (− 2.6; − 1.0) | 0.004 |
| EPLW(mL/kg) | 8 (7; 12) | 9 (8; 11) | 0 (− 1; 1) | 0.91 |
| CVP (mmHg) | 8 (5; 8) | 8 (6; 12) | 1 (0; 2) | 0.58 |
| GEF (%) | 20 (17; 21) | 17 (15; 19) | − 3 (− 3; − 2) | 0.004 |
| Diuresis (mL/h) | 100 (50; 150) | 50 (10; 70) | − 60 (− 90; − 50) | 0.016 |
| SvcO2 (%) | 73.6 (70.0; 87.0) | 75.3 (71.0; 77.0) | − 3.5 (− 7.0; 3.5) | 0.47 |
| DO2i (ml/min/m−2) | 444 (333; 615) | 366 (319; 437) | − 68 (− 98; − 64) | 0.031 |
| VO2i (ml/min/m−2) | 79 (61; 119) | 93 (72; 96) | − 6 (− 13; 16) | 0.84 |
| Norepinephrine (µg/kg) | 29.7 (20.2–50) | 38.1 (18.1–66.5) | 10.4 (5.7–25.5) | 0.027 |
HO O hours (baseline), H6 6 h, SAP systolic arterial pressure, DAP diastolic arterial pressure, MAP mean arterial pressure, Double product SAP x HR, CI cardiac index, SVi indexed stroke volume, CPI cardiac power index, SVRi indexed systemic vascular resistances, CFI cardiac function index, EPLW extra pulmonary lung water, CVP central venous pressure, GEF global ejection fraction, SvcO2 central venous oxygen saturation, DO2i indexed oxygen delivery, VO2i indexed oxygen consumption, norepinephrine = hourly amount of norepinephrine