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. 2021 Jan 7;22:37. doi: 10.1186/s12864-020-07333-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — a The differentially expressed genes (DEGs) of gut microbiota within different comparison groups at the KEGG module level. DEGs of gut microbiota at gene level in P-limited diet (b) and N-limited diet (c) with important items highlighted. The important items (i.e. the short fatty acid synthesis, ATP synthesis, nitrogen and phosphorus assimilation, and polyphosphate synthesis related genes): acnB (K01682): aconitate hydratase 2 / 2-methylisocitrate dehydratase; aspC (K00813): aspartate aminotransferase; crr (K02777): PTS system, glucose-specific IIA component; cydA (K00425): cytochrome d ubiquinol oxidase subunit I; dmsB (K00184): dimethyl sulfoxide reductase iron-sulfur subunit; dmsC (K00185): dimethyl sulfoxide reductase membrane subunit; DUT (K01520): dUTP pyrophosphatase; fadN (K07516): 3-hydroxyacyl-CoA dehydrogenase; fbp (K03841): fructose-1,6-bisphosphatase I; gcvP (K00281): glycine dehydrogenase; gdhA (K00261): glutamate dehydrogenase (NAD(P)+); glmM (K03431): phosphoglucosamine mutase; glnA (K01915): glutamine synthetase; gltS (K00284): glutamate synthase (ferredoxin); IDH1(K00031): isocitrate dehydrogenase; metZ (K10764): O-succinylhomoserine sulfhydrylase; pdhC (K00627): pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase); phoA (K01077): alkaline phosphatase; PPK (K00937): polyphosphate kinase; ppnN (K06966): uncharacterized protein; ppsA (K01007): pyruvate, water dikinase; prsA (K00948): ribose-phosphate pyrophosphokinase; pstS (K02040): phosphate transport system substrate-binding protein; purK (K01589): 5-(carboxyamino) imidazole ribonucleotide synthase; purN (K11175): phosphoribosylglycinamide formyltransferase 1; pycA (K01959): pyruvate carboxylase subunit A; pycB (K01960): pyruvate carboxylase subunit B; sdhB (K00240): succinate dehydrogenase / fumarate reductase, iron-sulfur subunit; sucD (K01902): succinyl-CoA synthetase alpha subunit; xdhA (K13481): xanthine dehydrogenase small subunit