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. 2020 Dec 16;21(2):146. doi: 10.3892/etm.2020.9577

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Copyright: © Li et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Establishment of the DEX-induced muscle atrophy cell model. (A) and (B) C2C12 myotubes in the DEX-induced muscle atrophy group were thinner than that of the control group under optical microscope. (C) The average area of C2C12 myotubes was lower in DEX-induced muscle atrophy C2C12 cells than in control cells. An increase in the mRNA levels of (D) MURF1 and (E) Atrogin-1 was observed in starved C2C12 cells. (F) An increase in the protein levels of MURF1 and Atrogin-1 was observed in starved C2C12 cells. ^*P<0.05 and ^***P<0.001 vs. control. DEX, dexamethasone; MURF1, muscle RING finger protein 1.