Infiltration and sealing for managing non-cavitated proximal lesions: a systematic review and meta-analysis

Outcomes	Plain language statements	Absolute effect		Relative effect (95% CI)	Certainty of the evidence GRADE
Outcomes	Plain language statements	With non-invasive treatments	With micro-invasive treatments	Relative effect (95% CI)	Certainty of the evidence GRADE
Measures	Lesions progression after infiltration or sealing	432	149	OR:0.23 (0.18–0.30)	⊕ ⊕ ⊕ ○ moderate
Measures	Lesions progression after infiltration or sealing	283 fewer per 1000 patients (95% CI 312–246 fewer per 1000 patients)		OR:0.23 (0.18–0.30)	⊕ ⊕ ⊕ ○ moderate
Measures: infiltration	Lesions progression after infiltration	396	121	OR:0.21 (0.15–0.29)	⊕ ⊕ ⊕ ○ moderate
Measures: infiltration	Lesions progression after infiltration	275 fewer per 1000 patients (95% CI 306–236 fewer per 1000 patients)		OR:0.21 (0.15–0.29)	⊕ ⊕ ⊕ ○ moderate
Measures: sealing	Lesions progression after sealing	502	214	OR:0.27 (0.18–0.42)	⊕ ⊕ ⊕ ○ moderate
Measures: sealing	Lesions progression after sealing	288 fewer per 1000 patients (95% CI 348–205 fewer per 1000 patients)		OR:0.27 (0.18–0.42)	⊕ ⊕ ⊕ ○ moderate