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. Author manuscript; available in PMC: 2021 Jan 8.
Published in final edited form as: Exp Neurol. 2019 Nov 26;324:113135. doi: 10.1016/j.expneurol.2019.113135

Fig. 4.

Fig. 4.

Post-injury administration of PFT-μ at 5 h after TBI decreased annexin V positive neurons in the cortical contusion region at 24 h. (A) Co-immunohistochemistry of annexin V and NeuN in the cortical region. Annexin V (a marker of apoptosis) immunoreactivity is shown in green, and NeuN (a cell marker for neurons) is shown in red. Yellow labelling indicates colocalization. (B) A representative HE-stained coronal section showing the area as indicated by the black (ipsilateral cortex) square box to compare the fluorescent signals across the 4 groups of rats. (C) There was a significant decrease in the number of Annexin V positive neurons in the TBI + PFT-μ group. Data are expressed as means ± SEM (n = 5 per group). ***P < .001, compared with the sham group; ###P < .001, versus the TBI + veh group; +++P < .001 versus the TBI + PFT-α group. Scale bar = 50 um.