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. 2021 Jan 7;12:22. doi: 10.1186/s13287-020-02059-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — a The experimental protocol. The mouse CI model was induced by BCCAO for 20 min. Experimental mice were started to receive either CGP (10 mg/kg; i.p.) or an equal volume of vehicle (0.1 M PBS, i.p.) at day 1 after CI. HE staining was performed for morphological changes at days 7 after CI. BrdU (50 mg/kg; i.p.) was administrated daily for 4 consecutive days from 9 to 12 days after CI. And then mice were sacrificed for immunofluorescence staining (BrdU, DCX, NeuN) at 14 and 28 days after CI. Morris water maze (MWM) test was conducted to evaluate the spatial learning and memory abilities at days 28 after CI. b, c Effect of CGP on CI-induced histological changes in hippocampal CA1 neurons (n = 5 mice in each group). b Microphotographs of HE staining in hippocampal CA1 7 days after reperfusion (scale bar 100 μm). c Histogram showing the number of CA1 neurons in hippocampal (the data are expressed as the mean ± SD). ^##P < 0.01 compared with the sham group (one-way ANOVA with Tukey post-test)