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. 2021 Jan 7;21:19. doi: 10.1186/s12906-020-03186-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — a,b,c,d,e. Microscopic images of liver tissue in the groups under study. a: Control negative group, showing the normal histological structure of hepatic tissue with normal cells (red arrow) and vein (black arrow), b: Control positive group, showing fatty infiltrated and degenerated hepatocyte (red arrow), congested vein and sinusoids (black arrow), degenerated biliary duct (orange arrow) and bridging necrotic cells (blue arrow), c: Green coffee methanolic extract group, showing nearly normal hepatocytes (red arrow) with mildly inflammated vein (black arrow). d: Silymarin group, showing mild fatty degeneration, mild inflammation and interstitial edema (red arrow) with normal vein (black arrow). e: Combination of green coffee methanolic extract and silymarin group, showing nearly normal hepatocytes (red arrow) and vein (black arrow). (X 400, H&E stains)