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BRD4 protein–protein interaction (PPI) profile. Via the acetyl-lysine (KAc) binding pocket in BDs, BRD4 binds to acetylated-histones in chromatin and serves as a scaffolding platform for recruiting a spectrum of partner proteins through the PPI via domains such as ET, CTD (c-terminal domain), and PID (p-TEF-interacting domain). BRD4-interacting proteins include mediator, transcription factor, p-TEFb/CDK9, chromatin modifiers and modelers, and likely those not yet identified
