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. 2021 Jan 7;12:44. doi: 10.1186/s13287-020-02107-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Secretory profiling of Crude and CD146-selected IFP-MSC spheroids with and without exposure to inflammatory/fibrotic cues. a, b Crude and CD146-selected IFP-MSC spheroids show similar inflammation-related secretory profiles both in non-induced and TI- or TIC-induced conditions. However, their secretory profiles of reparative growth factors were distinct and characterized by the secretion of different numbers and types of proteins. Heat maps’ colors are assigned according to a molecule concentration relative scale, from 0 to 10,000 (n = 2). c In both TI- and TIC-induced conditions, CD146POS IFP-MSC spheroids show higher number of secreted proteins. Among the proteins with upregulated secretion levels, 6 and none proteins are commonly shared between the three different cohorts (Crude, CD146POS, CD146NEG) after TI and TIC induction, respectively. Venn diagram showing shared proteins among the three different cohorts (Crude, CD146POS, CD146NEG) after TI and TIC induction. All experiments were performed independently (n = 2). d In non-induced cohorts, IDO secretion is almost absent whereas PGE2 secretion is evident in all three cohorts. TIC induction results in increased IDO and PGE2 secretion levels (*p < 0.05, n = 3)