Table 2.
Comparison of Patient Demographics by Trough Concentration
| Characteristics | Vancomycin Trough Serum Concentration, mg/L | p value | ||
|---|---|---|---|---|
| Trough <10 (n = 40) | Trough 10–20 (n = 27) | Trough >20 (n = 7) | ||
| Gestational age at birth, mean ± SD (range), wk | 26.7 ± 4 (22.4–35.6) | 26.2 ± 3.7 (22–38.6) | 25.5 ± 1.6 (22.4–27.2) | 0.71 |
| Corrected gestation age, mean ± SD (range), wk | 31.1 ± 4.4 (24.2–40.4) | 30.7 ± 3.8 (25.1–42.3) | 32.4± 2 (29.1–35.3) | 0.61 |
| Birth weight, mean ± SD (range), g | 859.4 ± 384 (470–1895) | 799.4 ± 348.2 (450–1775) | 677.1 ± 143.8 (480–880) | 0.43 |
| Weight at time of vancomycin initiation, mean ± SD (range), kg | 1.2 ± 0.5 (0.5–2.2) | 1.1 ± 0.4 (0.6–1.9) | 1.1 ± 0.3 (0.6–1.5) | 0.52 |
| Sex, n (%) | ||||
| Male | 24 (60) | 14 (51.9) | 3 (42.9) | 0.66 |
| Female | 16 (40) | 13 (48.2) | 4 (57.1) | |
| Diagnosis, n (%) | ||||
| Gastrointestinal | 27 (67.5) | 18 (66.7) | 5 (71.4) | |
| Neurosurgical | 8 (20) | 4 (14.8) | 1 (14.3) | |
| Infectious | 1 (2.5) | 2 (7.4) | 1 (14.3) | 0.92 |
| Miscellaneous* | 2 (5) | 2 (7.4) | 0 (0) | |
| Respiratory | 2 (5) | 1 (3.7) | 0 (0) | |
* Miscellaneous diagnoses: choanal atresia, congenital anomalies, incarcerated hernia, and neonatal hemochromatosis.