Table 8.

Melatonin Studies in Children With Atopic Dermatitis in Taiwan

Reference	N (age range, yr)	Melatonin Dosage	Duration	Summary/Comments
Chang81	48 (1–18)	3 mg/day	4 wk of tx followed by 2 wk washout period and alternative tx for 4 wk	Postrandomization individuals diagnosed with atopic dermatitis received either placebo or melatonin. Individuals on melatonin had a lower SCORing Atopic Dermatitis (SCORAD) index by 9.1 as compared with placebo (95% CI, −13.7 to −4;6; p < 0.001). Sleep onset occurred 21.4 min sooner with melatonin (95% CI, −38.6 to −4.2; p = 0.02). No SEs were noted.