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. 2021 Jan 7;11:9. doi: 10.1186/s13578-020-00525-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Selonsertib administration ameliorates LPS/GalN-induced liver failure. a Serum levels of ALT, AST, and TBIL were elevated by LPS/GalN injection (vehicle group) and decreased by selonsertib treatment in a dose-dependent manner. b Pathological changes in the liver tissue were shown using H&E staining. c The serum levels of inflammatory cytokines were determined by CBA cytokine analysis. d, e Western blot analysis and grey value assay of p-JNK and JNK expression levels in murine liver samples from different groups (2 from 6 samples are shown in the blots). f, f Serum levels of ALT, AST, and TBIL (f) and H&E staining (g) in LPS/GalN-injected mice treated with vehicle, selonsertib, or selonsertib combined with anisomycin. Data are presented as the mean ± SD (n = 6). *P < 0.05 vs. vehicle; **P < 0.01 vs. vehicle; ***P < 0.001 vs. vehicle; ^#P < 0.05; ^##P < 0.01; ^###P < 0.001; ns not significant, NC normal control, SEL15 selonsertib (15 mg/kg), SEL30 selonsertib (30 mg/kg), SEL60 selonsertib (60 mg/kg), AN anisomycin (20 mg/kg)