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. 2021 Jan 7;11:9. doi: 10.1186/s13578-020-00525-w

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — The therapeutic efficacy of selonsertib is related to JNK mitochondrial translocation. a, b Western blot analysis and grey value assay of p-JNK and JNK levels in murine whole liver samples (a) and the mitochondrial fraction of liver samples (b); 1 or 2 from 6 samples are shown in the blots. c Serum levels of ALT, AST, and TBIL in different groups with selonsertib pretreatment (Pre) or treatment at 0.5 h, 1 h, 2 h, and 4 h after LPS/GalN injection. d Pathological changes in the liver tissue were shown by H&E staining. e The serum levels of inflammatory cytokines and chemokines were determined by CBA cytokine analysis. f, g Western blot analysis of p-JNK and JNK levels in murine whole liver samples (f) and the mitochondrial fraction of liver samples (g) at initial (0 h) and 0.5 h, 1 h, 2 h, and 4 h after LPS/GalN injection (2 from 6 samples are shown in the blots). Data are presented as the mean ± SD (n = 6). *P < 0.05 vs. vehicle; **P < 0.01 vs. vehicle; ***P < 0.001 vs. vehicle; ^##P < 0.01 vs. vehicle; ^###P < 0.001 vs. vehicle; ns not significant vs. vehicle, NC normal control, SEL selonsertib (30 mg/kg)