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Survivin and interaction with apoptotic pathways. a Schematic representation of Survivin domains and their function. b Survivin interferes with the extrinsic apoptotic pathway through the inhibition of the death receptor/FADD-mediated signaling and the indirect inhibition of casp-8. Survivin also interacts with XIAP, XAF1 and HBXIP in a complex able to inhibit both the initiator casp-9 and the effectors casp-3 and casp-7
