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. 2021 Jan 7;22:36. doi: 10.1186/s12864-020-07329-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Log₂ foldchange (log₂ FC) for the expression of genes in ovary in relation to change in methylation level of a CpG site in RBCs within the TSS region (green), promoter region (blue) or 10 kb up- and downstream region and gene body (all grey) of that gene for Δ_1,2 (a) and Δ_2,3 (b). See Additional files 37 and 38; Tables S18 and S19 for the number of sites and genes for Δ_1,2 (a) and Δ_2,3 (b), respectively. The four quadrants (see ‘Methods’) are separated by dotted lines and labeled as ‘Q1-Q4’. Transparency is applied to the grey data points such that the area of overlap between plots appears darker