Table 1.
Baseline Characteristics of the Study Participants
| Non‐CKD | CKD | P value | |
|---|---|---|---|
| No. | 679 | 258 | |
| Follow‐up, y | 8.9 (6–10) | 7.6 (4–9) | <0.00001 |
| Age, y | 65 (57–72) | 74 (66–79) | <0.00001 |
| Men | 555 (82) | 217 (84) | 0.39 |
| Ethnicity | |||
| White | 401 (59) | 164 (64) | 0.6 |
| Black | 116 (17) | 35 (14) | |
| Asian | 80 (12) | 27 (11) | |
| Latino | 60 (9) | 22 (9) | |
| Diabetes mellitus | 166 (24) | 80 (31) | 0.04 |
| Current smoker | 152 (22) | 32 (12) | 0.003 |
| Event rate, %/y | 5.4 | 10.6 | |
| Events during follow‐up, No. | 284 (42) | 180 (70) | <0.00001 |
| Time to event, y | 8.9 (4.3–9) | 5 (1.9–8.9) | <0.00001 |
| BMI, kg/m2 | 27.7 (24.8–31.4) | 27.4 (24.9–30.5) | 0.37 |
| HDL‐C, mg/dL | 43 (36–54) | 42 (34–52) | 0.1 |
| LDL‐C, mg/dL | 99 (82–124) | 99 (82–119) | 0.32 |
| Total cholesterol, mg/dL | 173 (150–199) | 168 (146–195) | 0.12 |
| Triglycerides, mg/dL | 108 (71–166) | 119 (81–173) | 0.12 |
| Creatinine, mg/dL | 0.8 (0.9–1.1) | 1.4 (1.2–1.6) | <0.00001 |
| eGFR, mL/min per 1.73 m2 | 80.9 (71.1–93.1) | 50.0 (40.1–55.4) | <0.00001 |
| CRP, mg/L | 2.1 (0.8–4.7) | 2.7 (1.1–6.3) | 0.004 |
| Systolic blood pressure, mm Hg | 130 (118–143) | 135 (120–148) | 0.001 |
| Diastolic blood pressure, mm Hg | 74 (68–80) | 72 (68–80) | 0.41 |
Continuous measures are presented as median (interquartile range); categorical measures are presented as n (%) of the column total. BMI indicates body mass index; CKD, chronic kidney disease; CRP, C‐reactive protein; eGFR, estimated glomerular filtration rate; HDL‐C, high‐density lipoprotein cholesterol; and LDL, low‐density lipoprotein cholesterol.