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. 2021 Jan 7;9:10. doi: 10.1186/s40478-020-01104-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — CAA in aged pinniped brains (case No. 9). Congo red-positive amyloid deposition was observed on the blood vessels of the meninges (a) and cerebral cortex (b). These deposits showed typical apple-green birefringence under polarized light (inset). Immunohistochemically, amyloid deposits of the vessel wall were positive for Aβ40 (c), Aβ42 (d), AβpN3 (e), AβN1 (f), and ApoE (g). Scale bars: 100 μm (a); 50 μm (b–g)