Table 3.
HPV genotypes in single, multiple, and mixed-HPV infections in cervix without SIL, with SIL and CC
| O-Risk | NSIL | LSIL | HSIL | CC | |||||
|---|---|---|---|---|---|---|---|---|---|
| n = 239 | % | n = 901 | % | n = 54 | % | n = 291 | % | ||
| HPV negative | 74 | 30.9 | 1 | 0.1 | 0 | 0.0 | 5 | 1.7 | |
| Single HPV infection | |||||||||
| 16 | HR | 40 | 16.7 | 119 | 13.2 | 7 | 13.0 | 123 | 42.3 |
| 18 | HR | 4 | 1.7 | 13 | 1.4 | 3 | 5.6 | 23 | 7.9 |
| 51 | HR | 6 | 2.5 | 19 | 2.1 | 1 | 1.8 | 0 | 0.0 |
| 52 | HR | 2 | 0.8 | 19 | 2.1 | 0 | 0.0 | 4 | 1.4 |
| 45 | HR | 1 | 0.4 | 7 | 0.8 | 1 | 1.8 | 13 | 4.5 |
| 66 | PHR | 7 | 2.9 | 41 | 4.4 | 2 | 3.7 | 0 | 0.0 |
| 53 | PHR | 9 | 3.8 | 23 | 2.5 | 1 | 1.8 | 0 | 0.0 |
| 68 | PHR | 0 | 0.0 | 10 | 1.1 | 0 | 0.0 | 1 | 0.3 |
| 26 | PHR | 0 | 0.0 | 2 | 0.2 | 0 | 0.0 | 1 | 0.3 |
| 83 | PHR | 0 | 0.0 | 3 | 0.3 | 0 | 0.0 | 0 | 0.0 |
| 6 | LR | 15 | 6.3 | 62 | 6.9 | 0 | 0.0 | 1 | 0.3 |
| 70 | LR | 1 | 0.4 | 8 | 0.9 | 0 | 0.0 | 0 | 0.0 |
| 11 | LR | 0 | 0.0 | 7 | 0.8 | 0 | 0.0 | 1 | 0.3 |
| 54 | LR | 0 | 0.0 | 8 | 0.9 | 0 | 0.0 | 0 | 0.0 |
| 44 | LR | 2 | 0.8 | 5 | 0.5 | 0 | 0.0 | 0 | 0.0 |
| 74 | UR | 2 | 0.8 | 10 | 1.1 | 0 | 0.0 | 0 | 0.0 |
| 62 | UR | 0 | 0.0 | 4 | 0.4 | 0 | 0.0 | 0 | 0.0 |
| 69 | UR | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 4 | 1.4 |
| 89 | UR | 0 | 0.0 | 2 | 0.2 | 0 | 0.0 | 0 | 0.0 |
| 67 | UR | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 1 | 0.3 |
| Multiple HPV infection | |||||||||
| 16 and 52 | HR | 0 | 0.0 | 7 | 0.8 | 1 | 1.8 | 6 | 2.0 |
| 31 and 33 | HR | 1 | 0.4 | 6 | 0.7 | 4 | 7.4 | 3 | 1.0 |
| 16 and 18 | HR | 0 | 0.0 | 8 | 0.9 | 1 | 1.8 | 4 | 1.4 |
| 16 and 56 | HR | 1 | 0.4 | 4 | 0.4 | 1 | 1.8 | 0 | 0.0 |
| 16 and 39 | HR | 0 | 0.0 | 2 | 0.2 | 0 | 0.0 | 2 | 0.7 |
| 53 and 66 | PHR | 1 | 0.4 | 6 | 0.7 | 0 | 0.0 | 0 | 0.0 |
| 58 and 68 | PHR | 0 | 0.0 | 2 | 0.2 | 0 | 0.0 | 0 | 0.0 |
| 66 and 53 | PHR | 0 | 0.0 | 2 | 0.2 | 0 | 0.0 | 0 | 0.0 |
| 66 and 68 | PHR | 0 | 0.0 | 1 | 0.1 | 0 | 0.0 | 0 | 0.0 |
| 11 and 54 | LR | 1 | 0.4 | 1 | 0.1 | 0 | 0.0 | 0 | 0.0 |
| 6 and 11 | LR | 0 | 0.0 | 0 | 0.0 | 1 | 1.8 | 0 | 0.0 |
| 6 and 54 | LR | 0 | 0.0 | 1 | 0.1 | 0 | 0.0 | 0 | 0.0 |
| 6 and 7 | LR | 0 | 0.0 | 1 | 0.1 | 0 | 0.0 | 0 | 0.0 |
| 6 and 70 | LR | 0 | 0.0 | 1 | 0.1 | 0 | 0.0 | 0 | 0.0 |
| 69 and 71 | UR | 1 | 0.4 | 3 | 0.3 | 1 | 1.8 | 0 | 0.0 |
| Mixed HPV infection | |||||||||
| 16 and 6 | HR, LR | 4 | 1.7 | 20 | 2.2 | 1 | 1.8 | 3 | 1.0 |
| 53 and 6 | PHR, LR | 0 | 0.0 | 8 | 0.9 | 0 | 0.0 | 0 | 0.0 |
| 16 and 53 | HR, PHR | 1 | 0.4 | 6 | 0.7 | 0 | 0.0 | 0 | 0.0 |
| 66 and 6 | PHR, LR | 0 | 0.0 | 6 | 0.7 | 0 | 0.0 | 1 | 0.3 |
| 39 and 6 | HR, LR | 0 | 0.0 | 4 | 0.4 | 0 | 0.0 | 2 | 0.7 |
| 68 and 6 | PHR, LR | 1 | 0.4 | 5 | 0.5 | 0 | 0.0 | 0 | 0.0 |
| 16 and 68 | HR, PHR | 0 | 0.0 | 5 | 0.5 | 0 | 0.0 | 0 | 0.0 |
| 16 and 66 | HR, PHR | 0 | 0.0 | 4 | 0.4 | 0 | 0.0 | 0 | 0.0 |
| 18 and 6 | HR, LR | 0 | 0.0 | 3 | 0.3 | 0 | 0.0 | 1 | 0.3 |
O-Risk Oncogenic risk, NSIL Non-squamous intraepithelial lesions, LSIL Low-grade squamous intraepithelial lesions, HSIL High-grade squamous intraepithelial lesions, CC Cervical cancer, HR High risk, PHR Probably high risk, LR Low risk, UR Indeterminate risk. Single HPV Infection with one genotype (shown are the five most prevalent genotypes by risk group), Multiple HPV Infection with two genotypes of the same risk group (shown are the most prevalent genotypes by risk group), Mixed HPV Infection with genotypes of different risk groups (shown are the most prevalent combinations)