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. 2021 Jan 7;21:34. doi: 10.1186/s12935-020-01736-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — The features of circNEIL3 in cervical cancer. a The exonic information of circNEIL3 was illustrated as indicated. b qRT-PCR assay with convergent or divergent primers indicating the existence of circNEIL3 in SiHa cells. c The expressions of circNEIL3 and linear mRNA in SiHa cells were detected by qRT-PCR in the presence or absence of RNase R. d qRT–PCR analysis for the expression of circNEIL3 and NEIL3 mRNAs after treatment with Actinomycin D in SiHa cells. e Nuclear-cytoplasmic fractionation experiment showing that circNEIL3 was mainly distributed in the cytoplasm. f FISH for circNEIL3. Nuclei were stained with DAPI. Data were represented as means ± S.D. of at least three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001