Table 2.

Association Between PAQ Score and Outcomes

Clinical Outcome	Unadjusted		Adjusted
	HR (95% CI)	P Value*	HR (95% CI)	P Value*
MACE†	0.88 (0.85–0.91)	<0.0001	0.92 (0.88–0.96)	<0.0001
MALE‡	0.91 (0.84–0.98)	0.0101	0.91 (0.83–1.00)	0.0420
ALI requiring hospitalization§	0.99 (0.90–1.08)	0.8294	0.98 (0.89–1.08)	0.6716
Major amputation‖	0.83 (0.74–0.92)	0.0006	0.86 (0.75–0.98)	0.0242
LER¶	0.90 (0.88–0.92)	<0.0001	0.90 (0.88–0.93)	<0.0001

ALI indicates acute limb ischemia; EQ‐5D, EuroQol 5‐Dimensions; HR, hazard ratio; LER, lower‐extremity revascularization; MACE, major adverse cardiovascular events; MALE, major adverse limb events; and PAQ, peripheral artery questionnaire.

^*We used a Cox proportional hazards model, landmarked at 12 months and controlled for the baseline scores in all unadjusted and adjusted models.

^†Adjusted for Rutherford score, sex, prior stroke, prior carotid revascularization, prior myocardial infarction (MI), prior percutaneous coronary intervention (PCI), prior coronary artery bypass graft (CABG), diabetes mellitus, statin use, tobacco use, prior minor amputation, age, ankle–brachial index (ABI), estimated glomerular filtration rate (eGFR), ticagrelor (study arm).

^‡Adjusted for Rutherford score, inclusion criteria, prior carotid revascularization, diabetes mellitus, prior major amputation, statin use, ABI, region, and tobacco use, ticagrelor (study arm).

^§Adjusted for inclusion criteria, prior carotid revascularization, statin use, eGFR, ticagrelor (study arm).

^‖Adjusted for Rutherford score, prior carotid revascularization, diabetes mellitus, prior major amputation, prior minor amputation, ABI, ticagrelor (study arm).

^¶Adjusted for inclusion criteria, region, ABI, tobacco use, prior clopidogrel use, eGFR, ticagrelor (study arm).