Table 2.
Death Prediction Models
| Variables | Base Model | Base Model+N‐TproBNP | NT‐proBNP by Itself | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (20 Variables; C‐Statistic, 0.744 [95% CI, 0.722–0.767]) | (21 Variables; C‐Statistic, 0.779 [95% CI, 0.758–0.800]) | (1 Variable; C‐Statistic, 0.745 [95% CI, 0.723–0.768]) | ||||||||||
| HR | 95% CI | P Value | χ2 | HR | 95% CI | P Value | χ2 | HR | 95% CI | P Value | χ2 | |
| Log NT‐proBNP, per 1 log unit | … | … | … | … | 1.62 | 1.49–1.77 | <0.001 | 118.6 | 1.94 | 1.81–2.07 | <0.001 | 383.4 |
| Log hs‐TnT, per 1 log unit | 1.85 | 1.63–2.11 | <0.001 | 85.0 | 1.49 | 1.29–1.71 | <0.001 | 30.8 | ||||
| Age, per 10 y | 1.57 | 1.39–1.77 | <0.001 | 54.0 | 1.43 | 1.26–1.61 | <0.001 | 32.8 | ||||
| Albumin, per 1 mg/dL | 0.55 | 0.43–0.69 | <0.001 | 25.2 | 0.77 | 0.6–0.98 | 0.035 | 4,.5 | ||||
| History of HF | 1.79 | 1.41–2.28 | <0.001 | 22.7 | 1.42 | 1.11–1.81 | 0.005 | 7.9 | ||||
| Heart rate, per 10 beats/min | 1.10 | 1.02–1.19 | 0.015 | 5.9 | 1.13 | 1.05–1.22 | 0.002 | 9.5 | ||||
| History of stroke | 1.38 | 1.06–1.80 | 0.02 | 5.8 | 1.43 | 1.10–1.87 | 0.008 | 7.1 | ||||
| HbA1c, per 1% | 1.08 | 1.01–1.14 | 0.02 | 5.7 | 1.09 | 1.02–1.15 | 0.007 | 7.2 | ||||
| Smoking | 1.17 | 1.02–1.35 | 0.03 | 4.9 | 1.17 | 1.01–1.34 | 0.03 | 4.6 | ||||
| LVH on ECG | 1.38 | 1.03–1.86 | 0.03 | 4.6 | 1.17 | 0.87–1.57 | 0.30 | 1.1 | ||||
| Q wave on ECG | 1.38 | 1.02–1.87 | 0.04 | 4.3 | 1.12 | 0.82–1.53 | 0.47 | 0.5 | ||||
| History of AF | 1.31 | 1.00–1.71 | 0.05 | 3.8 | 0.99 | 0.76–1.29 | 0.93 | 0.0 | ||||
| BB on ECG | 1.27 | 1.00–1.62 | 0.05 | 3.7 | 1.07 | 0.84–1.38 | 0.57 | 0.3 | ||||
| Log UACR, per 1 log unit | 1.05 | 0.99–1.11 | 0.10 | 2.7 | 1.03 | 0.98–1.10 | 0.24 | 1.4 | ||||
| SBP, per 10 mmHg | 1.05 | 0.98–1.12 | 0.15 | 2.0 | 1.03 | 0.97–1.10 | 0.33 | 0.9 | ||||
| Female sex | 1.16 | 0.92–1.46 | 0.22 | 1.5 | 0.95 | 0.75–1.21 | 0.67 | 0.2 | ||||
| History of CHD | 1.14 | 0.92–1.42 | 0.22 | 1.5 | 0.97 | 0.79–1.20 | 0.79 | 0.1 | ||||
| LDL‐C, 1 mg/dL | 1.00 | 1.00–1.00 | 0.24 | 1.4 | 1.00 | 1.00–1.01 | 0.02 | 5.9 | ||||
| eGFR, per 10 mL/min/1.73 m2 | 0.97 | 0.92–1.03 | 0.34 | 0.9 | 1.01 | 0.96–1.07 | 0.67 | 0.2 | ||||
| Insulin use | 1.05 | 0.85–1.28 | 0.66 | 0.2 | 1.13 | 0.92–1.39 | 0.26 | 1.3 | ||||
| DBP, per 10 mm Hg | 1.01 | 0.90–1.13 | 0.86 | 0.0 | 0.98 | 0.87–1.09 | 0.70 | 0.2 | ||||
AF indicates atrial fibrillation; BB, any bundle‐branch block; CHD, coronary heart disease; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; HbA1c, glycated hemoglobin; HF, heart failure; HR, hazard ratio; hs‐TnT, high‐sensitivity cardiac troponin; LDL‐C, low‐density lipoprotein cholesterol; LVH, left ventricular hypertrophy; NT‐proBNP, N‐terminal pro‐B‐type natriuretic peptide; SBP, systolic blood pressure; UACR, urine albumin‐to‐creatinine ratio.