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. 2020 Sep 23;9(19):e017462. doi: 10.1161/JAHA.120.017462

Table 3.

CVCO Prediction Models

Variables Base Model Base Model+NT‐proBNP NT‐proBNP by Itself
(20 Variables; C‐Statistic, 0.731 [95% CI, 0.714–0.749]) (21 Variables; C‐Statistic, 0.763 [95% CI, 0.746–0.780]) (1 Variable; C‐Statistic, 0.723 [95% CI, 0.704–0.741])
HR 95% CI P Value χ2 HR 95% CI P Value χ2 HR 95% CI P Value χ2
Log NT‐proBNP, per 1 log unit … … … … 1.63 1.52–1.75 <0.001 189.9 1.88 1.78–1.98 <0.001 545.2
Log hs‐TnT, per 1 log unit 1.63 1.47–1.81 <0.001 86.5 1.31 1.18–1.47 <0.001 23.3
History of HF 2.11 1.75–2.55 <0.001 60.7 1.69 1.40–2.05 <0.001 29.6
Age, per 10 y 1.32 1.21–1.45 <0.001 34.8 1.21 1.10–1.33 <0.001 15.4
Albumin, per 1 mg/dL 0.58 0.48–0.70 <0.001 34.1 0.80 0.66–0.96 0.02 5.4
LDL‐C, 1 mg/dL 1.00 1.00–1.01 <0.001 17.3 1.01 1.00–1.01 <0.001 30.1
History of AF 1.49 1.21–1.85 <0.001 13.5 1.12 0.9–1.38 0.32 1.0
History of stroke 1.46 1.19–1.80 <0.001 13.0 1.51 1.23–1.86 <0.001 15.4
SBP, per 10 mmHg 1.09 1.04–1.15 0.001 11.8 1.07 1.02–1.12 0.01 6.7
HbA1c, per 1% 1.08 1.03–1.14 0.001 11.4 1.10 1.05–1.15 <0.001 15.5
Smoking 1.19 1.07–1.33 0.002 9.9 1.18 1.06–1.31 0.003 8.8
History of CHD 1.29 1.09–1.53 0.003 8.8 1.10 0.93–1.30 0.25 1.3
Female sex 1.26 1.05–1.51 0.01 6.5 1.04 0.87–1.25 0.65 0.2
Log UACR, per 1 log unit 1.06 1.01–1.11 0.012 6.4 1.04 1.00–1.09 0.057 3.6
BB on ECG 1.26 1.04–1.54 0.02 5.4 1.09 0.89–1.33 0.39 0.7
DBP, per 10 mm Hg 0.94 0.86–1.03 0.16 2.0 0.92 0.85–1.01 0.07 3.3
Insulin use 1.12 0.95–1.31 0.18 1.8 1.19 1.01–1.40 0.04 4.2
Q wave on ECG 1.16 0.90–1.49 0.26 1.3 0.93 0.71–1.20 0.57 0.3
Heart rate, per 10 bpm 1.03 0.97–1.10 0.32 1.0 1.06 1.00–1.13 0.06 3.6
LVH on ECG 1.10 0.86–1.42 0.43 0.6 0.94 0.73–1.20 0.60 0.3
eGFR, per 10 mL/min/1.73 m2 0.99 0.95–1.03 0.76 0.1 1.03 0.99–1.08 0.10 2.7

AF indicates atrial fibrillation; BB, any bundle‐branch block; CHD, coronary heart disease; CVCO, cardiovascular composite outcome; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; HbA1c, glycated hemoglobin; HF, heart failure; HR, hazard ratio; hs‐TnT, high‐sensitivity cardiac troponin; LDL‐C, low‐density lipoprotein cholesterol; LVH, left ventricular hypertrophy; NT‐proBNP, N‐terminal pro‐B‐type natriuretic peptide; SBP, systolic blood pressure; and UACR, urine albumin‐to‐creatinine ratio.