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. 2020 Oct 2;9(19):e018074. doi: 10.1161/JAHA.120.018074

Figure 6. Leptin treatment reduces ritonavir‐induced adrenergic hypercontractility via Nox1‐dependent mechanisms.

Figure 6

Concentration response curves to Phe (A through D) in presence or absence of l‐NAME (C and D) in aortic rings from wild type or Nox1‐deficient mice (Nox1−/−) (B and D) treated or not with ritonavir (5 mg/kg per day for 4 weeks, ip) in the presence or absence of leptin treatment (0.3 mg/kg per day for 1 week, via osmotic mini‐pump) (A and C). E, KCl induced vascular contraction. Data are presented as mean±SEM. N=3 to 7; *P<0.05 vs Ctrl. Ctrl indicates control; l‐NAME, l‐NG‐nitro arginine methyl ester; Nox1, NADPH oxidase 1; and Phe, phenylephrine.