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. Author manuscript; available in PMC: 2021 Jan 8.
Published in final edited form as: J Phys Chem B. 2020 Jun 4;124(28):5930–5939. doi: 10.1021/acs.jpcb.0c03028

Figure 4 – MAL displaces PLP from raft phase.

Figure 4 –

(A) Single transfected PLP and MAL both have preference for raft phase (non-raft labeled with F-DiO, white). Co-transfection reduces PLP raft preference to approximately equal partitioning between phases, but does not significantly affect MAL. (B) PLP partitioning is unaffected by co-transfection with LAT. (C) Raft partitioning of MAL (open symbols) and PLP (closed symbols) as a function of co-transfection (triangles) compared with single transfected (circles). PLP raft affinity is significantly reduced by co-transfection with MAL, (D) but not by the co-transfection with LAT. Partitioning in panel D shown as normalized by PLP alone. Bars represent average +/− s.e.m.; circles represent means of individual experiments (>10 vesicles each). **p<0.01 by t-test.