Figure 2.

Qualitative vs. quantitative measurement. Distribution of log-transformed IC₅₀ values grouped by qualitative measurement. Data are shown for (A) those entries of the data set provided by Jensen et al. [31], which can be mapped to the IEDB, and (B) the complete IEDB data set (HLA-DRB entries). IC₅₀ values were transformed as described by Jensen et al. ($1-log\left({\mathrm{IC}}_{50}\right)/log$(50,000)); therefore IC₅₀ values >50,000 nM were set to 50,000 nM beforehand. Entries defined as binders (Positive, Positive-Low, Positive-Intermediate, Positive-High) are shown in blue, non-binder (Negative) are shown in red. Mean values are indicated as dotted lines; the black dashed lines indicate ${\mathrm{IC}}_{50}=500$.