Table 2.

Association between predictive factors and overall survival of CRC in the training cohort.

Demographic or Characteristic	Univariate Analysis		Multivariate Analysis
	HR (95% CI)	p Value	HR (95% CI)	p Value
Age		<0.001		<0.001
<60	1.000		1.000
≥60	1.654 (1.479–1.851)		1.521 (1.354–1.708)
Gender		0.013		<0.001
Male	1.000		1.000
Female	0.866 (0.773–0.970)		0.802 (0.715–0.899)
Tumor location		<0.001		0.001
Colon	1.000		1.000
Rectum	1.297 (1.160–1.449)		1.224 (1.089–1.377)
Tumor diameter		<0.001		0.009
<50 mm	1.000		1.000
≥50 mm	1.248 (1.113–1.400)		1.171 (1.040–1.319)
Pathological classification
Prominence	1.000		1.000
Infiltration or Ulceration	1.544 (1.298–1.836)	<0.001	1.357 (1.138–1.619)	0.001
Infiltration and Ulceration	1.578 (1.394–1.786)	<0.001	1.394 (1.228–1.581)	<0.001
Differentiation degree
Well	1.000		1.000
Moderate	1.608 (1.243–2.079)	<0.001	1.480 (1.142–1.916)	0.003
Poor	2.812 (2.132–3.708)	<0.001	2.269 (1.715–3.003)	<0.001
Histologic classification		0.011		0.002
Adenocarcinoma	1.000		1.000
Mucinous adenocarcinoma or signet ring cell carcinoma	1.176 (1.039–1.332)		1.219 (1.073–1.385)
TNM staging		<0.001		<0.001
II	1.000		1.000
III	2.447 (2.187–2.738)		2.248 (1.995–2.534)
Nerve invasion		<0.001		0.001
No	1.000		1.000
Yes	1.774 (1.480–2.126)		1.387 (1.146–1.679)
Vascular tumor thrombus		<0.001		<0.001
No	1.000		1.000
Yes	2.435 (1.922–3.087)		1.669 (1.302–2.139)
CEA		<0.001		<0.001
<5 ng/mL	1.000		1.000
≥5 ng/mL	1.709 (1.521–1.921)		1.373 (1.217–1.550)
CA19-9		<0.001		<0.001
<37 U/mL	1.000		1.000
≥37 U/mL	2.012 (1.761–2.298)		1.525 (1.322–1.760)
Postoperative chemotherapy		<0.001		<0.001
No	1.000		1.000
Yes	0.669 (0.596–0.751)		0.578 (0.511–0.654)
Postoperative radiotherapy		<0.001		<0.001
No	1.000		1.000
Yes	1.854 (1.496–2.298)		1.824 (1.458–2.282)
OS-PII (Continuous)	1.105 (1.072–1.139)	<0.001	1.087 (1.052–1.122)	<0.001
OS-PII (Binary)		<0.001		<0.001
≤4.27	1.000		1.000
>4.27	1.400 (1.253–1.565)		1.330 (1.189–1.489)

Abbreviations: HR, hazard ratio; CI, confidence interval.