Table 3.

Association between predictive factors and disease-free survival of CRC in the training cohort.

Demographic or Characteristic	Univariate Analysis		Multivariate Analysis
	HR (95% CI)	p Value	HR (95% CI)	p Value
Age (year)		0.010		<0.001
<60	1.000		1.000
≥60	1.176 (1.040–1.331)		1.261 (1.109–1.433)
Gender		0.048		0.014
Male	1.000		1.000
Female	0.880 (0.776–0.999)		0.851 (0.749–0.968)
Tumor location		<0.001		<0.001
Colon	1.000		1.000
Rectum	1.633 (1.437–1.856)		1.504 (1.314–1.721)
Tumor diameter		0.004		0.008
<50 mm	1.000		1.000
≥50 mm	1.211 (1.063–1.379)		1.195 (1.047–1.362)
Pathological classification
Prominence	1.000		1.000
Infiltration or Ulceration	1.559 (1.288–1.888)	<0.001	1.395 (1.148–1.695)	0.001
Infiltration and Ulceration	1.498 (1.302–1.724)	<0.001	1.316 (1.141–1.518)	<0.001
Differentiation degree
Well	1.000		1.000
Moderate	1.336 (1.029–1.734)	0.030	1.257 (0.966–1.637)	0.088
Poor	2.161 (1.620–2.882)	<0.001	1.708 (1.275–2.287)	<0.001
Histologic classification		0.164		-
Adenocarcinoma	1.000		-
Mucinous adenocarcinoma or signet ring cell carcinoma	1.105 (0.960–1.273)		-
TNM staging		<0.001		<0.001
II	1.000		1.000
III	2.720 (2.396–3.088)		2.148 (1.878–2.457)
Nerve invasion		<0.001		<0.001
No	1.000		1.000
Yes	2.084 (1.728–2.513)		1.479 (1.212–1.805)
Vascular tumor thrombus		<0.001		<0.001
No	1.000		1.000
Yes	2.810 (2.203–3.584)		1.758 (1.361–2.273)
CEA		<0.001		0.001
<5 ng/mL	1.000		1.000
≥5 ng/mL	1.530 (1.347–1.738)		1.259 (1.100–1.442)
CA19-9		<0.001		<0.001
<37 U/mL	1.000		1.000
≥37 U/mL	1.914 (1.631–2.245)		1.594 (1.353–1.878)
Postoperative chemotherapy		<0.001		0.277
No	1.000		1.000
Yes	1.272 (1.125–1.439)		1.076 (0.943–1.229)
Postoperative radiotherapy		<0.001		<0.001
No	1.000		1.000
Yes	3.212 (2.623–3.932)		2.281 (1.839–2.828)
DFS-PII (Continuous)	1.105 (1.069–1.143)	<0.001	1.089 (1.053–1.128)	<0.001
DFS-PII (Binary)		<0.001		<0.001
≤4.47	1.000		1.000
>4.47	1.395 (1.233–1.580)		1.366 (1.206–1.548)

Abbreviations: HR, hazard ratio; CI, confidence interval.