Table 4.
Association between predictive factors and overall survival of CRC in the validation cohort.
| Demographic or Characteristic | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
| HR (95% CI) | p Value | HR (95% CI) | p Value | |
| Age | <0.001 | <0.001 | ||
| <60 | 1.000 | 1.000 | ||
| ≥60 | 1.418 (1.197–1.679) | 1.468 (1.235–1.745) | ||
| Gender | 0.508 | 0.604 | ||
| Male | 1.000 | 1.000 | ||
| Female | 1.059 (0.893–1.256) | 1.047 (0.881–1.244) | ||
| Tumor location | 0.397 | 0.653 | ||
| Colon | 1.000 | 1.000 | ||
| Rectum | 0.930 (0.786–1.100) | 0.958 (0.793–1.156) | ||
| Tumor diameter | 0.603 | 0.288 | ||
| <50 mm | 1.000 | 1.000 | ||
| ≥50 mm | 1.048 (0.878–1.252) | 1.106 (0.919–1.331) | ||
| Pathological classification | ||||
| Prominence | 1.000 | 1.000 | ||
| Infiltration or Ulceration | 1.488 (1.189–1.861) | 0.001 | 1.223 (0.972–1.539) | 0.086 |
| Infiltration and Ulceration | 1.616 (1.081–2.415) | 0.019 | 1.424 (0.948–2.139) | 0.088 |
| Differentiation degree | ||||
| Well | 1.000 | 1.000 | ||
| Moderate | 2.289 (0.570–9.196) | 0.243 | 1.350 (0.334–5.452) | 0.673 |
| Poor | 4.904 (1.218–19.745) | 0.025 | 2.096 (0.516–8.513) | 0.301 |
| Histologic classification | 0.001 | 0.634 | ||
| Adenocarcinoma | 1.000 | 1.000 | ||
| Mucinous adenocarcinoma or signet ring cell carcinoma | 1.413 (1.145–1.743) | 1.059 (0.838–1.338) | ||
| TNM staging | <0.001 | <0.001 | ||
| II | 1.000 | 1.000 | ||
| III | 2.985 (2.414–3.691) | 2.083 (1.648–2.634) | ||
| Nerve invasion | <0.001 | 0.010 | ||
| No | 1.000 | 1.000 | ||
| Yes | 1.950 (1.635–2.325) | 1.284 (1.062–1.551) | ||
| Vascular tumor thrombus | <0.001 | <0.001 | ||
| No | 1.000 | 1.000 | ||
| Yes | 2.774 (2.342–3.285) | 1.721 (1.427–2.076) | ||
| CEA | <0.001 | <0.001 | ||
| <5 ng/mL | 1.000 | 1.000 | ||
| ≥5 ng/mL | 2.375 (1.994–2.830) | 1.661 (1.376–2.006) | ||
| CA19-9 | <0.001 | <0.001 | ||
| <37 U/mL | 1.000 | 1.000 | ||
| ≥37 U/mL | 3.073 (2.583–3.654) | 1.917 (1.581–2.323) | ||
| Postoperative chemotherapy | 0.014 | <0.001 | ||
| No | 1.000 | 1.000 | ||
| Yes | 0.774 (0.631–0.949) | 0.618 (0.499–0.766) | ||
| Postoperative radiotherapy | 0.016 | 0.089 | ||
| No | 1.000 | 1.000 | ||
| Yes | 1.329 (1.055–1.675) | 1.257 (0.965–1.637) | ||
| OS-PII (Continuous) | 1.164 (1.107–1.224) | <0.001 | 1.133 (1.076–1.194) | <0.001 |
| OS-PII (Binary) | <0.001 | <0.001 | ||
| ≤4.27 | 1.000 | 1.000 | ||
| >4.27 | 1.561 (1.316–1.852) | 1.407 (1.182–1.674) | ||
Abbreviations: HR, hazard ratio; CI, confidence interval.