Table 5.

Association between predictive factors and disease-free survival of CRC in the validation cohort.

Demographic or Characteristic	Univariate Analysis		Multivariate Analysis
	HR (95% CI)	p Value	HR (95% CI)	p Value
Age (year)		0.291		0.108
<60	1.000		1.000
≥60	1.070 (0.944–1.212)		1.110 (0.978–1.261)
Gender		0.623		0.328
Male	1.000		1.000
Female	0.969 (0.853–1.100)		0.938 (0.825–1.067)
Tumor location		0.946		0.891
Colon	1.000		1.000
Rectum	1.004 (0.888–1.138)		0.990 (0.863–1.136)
Tumor diameter		0.266		0.951
<50 mm	1.000		1.000
≥50 mm	0.927 (0.810–1.060)		0.996 (0.866–1.144)
Pathological classification
Prominence	1.000		1.000
Infiltration or Ulceration	1.420 (1.208–1.668)	<0.001	1.193 (1.013–1.405)	0.035
Infiltration and Ulceration	1.414 (1.040–1.923)	0.027	1.232 (0.904–1.680)	0.187
Differentiation degree
Well	1.000		1.000
Moderate	1.796 (0.744–4.332)	0.192	1.149 (0.475–2.780)	0.758
Poor	2.965 (1.225–7.178)	0.016	1.435 (0.590–3.491)	0.426
Histologic classification		0.056		-
Adenocarcinoma	1.000		-
Mucinous adenocarcinoma or signet ring cell carcinoma	1.174 (0.996–1.384)		-
TNM staging		<0.001		<0.001
II	1.000		1.000
III	2.448 (2.112–2.837)		1.684 (1.429–1.984)
Nerve invasion		<0.001		<0.001
No	1.000		1.000
Yes	1.999 (1.755–2.277)		1.389 (1.207–1.597)
Vascular tumor thrombus		<0.001		<0.001
No	1.000		1.000
Yes	2.249 (1.983–2.551)		1.528 (1.327–1.758)
CEA		<0.001		<0.001
<5 ng/mL	1.000		1.000
≥5 ng/mL	2.004 (1.763–2.279)		1.589 (1.384–1.824)
CA19-9		<0.001		<0.001
<37 U/mL	1.000		1.000
≥37 U/mL	2.306 (2.015–2.639)		1.584 (1.364–1.841)
Postoperative chemotherapy		0.004		0.317
No	1.000		1.000
Yes	1.291 (1.087–1.534)		1.096 (0.916–1.312)
Postoperative radiotherapy		0.001		0.257
No	1.000		1.000
Yes	1.353 (1.133–1.615)		1.121 (0.920–1.366)
DFS-PII (Continuous)	1.054 (1.036–1.073)	0.003	1.037 (1.002–1.075)	0.040
DFS-PII (Binary)		0.001		0.019
≤4.47	1.000		1.000
>4.47	1.248 (1.101–1.414)		1.162 (1.025–1.318)

Abbreviations: HR, hazard ratio; CI, confidence interval.