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. 2020 Dec 22;13(1):2. doi: 10.3390/cancers13010002

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Serum AnxA2 levels in breast cancer patients. (A) Serum AnxA2 protein levels in breast cancer patients (n = 162) and normal healthy females (n = 65) were determined by ELISA. The data are presented as the mean ± SEM (****, p < 0.0001; two-tailed Students t-test). (B) Serum AnxA2 levels in different grades of breast cancer patients (Grade I, n = 15; grade II, n = 47; and grade III, n = 91). The data are presented as the mean ± SEM (^ns, non-significant; ****, p < 0.0001; one-way ANOVA followed by Tukey multiple comparison test). Overall survival (C) and diseases-free survival (D) of breast cancer patients with high and low serum AnxA2 levels. The p value was calculated using the log-rank test. (E) ROC curve for breast cancer patients (n = 162) versus normal healthy females (n = 65).